University of California

Cell4vet Corporation

Tom F Lue

Emil A Tanagho

Curtis A Gleason

Richard A Schmidt

Ching-Shwun Lin

Yuet W Kan

Guiting Lin

Rajvir Dahiya

Ching Shwun Lin

Gerald R Cunha

Ming C Wu

Marshall Leedy Stoller

Justin K Valley

Maurice Marcel Garcia

Aaron T Ohta

Peter Carroll

HongXiu Ning

Emil E Tanagho

The treatment of various sensitive organs with low energy acoustic shockwaves has been proposed. However, the prior art is lacking in guidance as to what constitutes an efficacious minimum dosage or a safe maximum dosage for various target organs and tissues. Through extensive experimentation with cultured cells, live animals, and animal disease models, the inventors of the present disclosure have determined safe and efficacious shockwave energetic dosage ranges for vital and sensitive organs, including the brain, pancreas, kidneys, liver, and spleen, as well as for skin and subcutaneous tissues, peripheral nerves, and skeletal muscles.

Optimal dosages for low energy shock wave treatment of vital organs

The invention provides for compositions and methods for making and using adipose-derived stem cells for treating non-human mammals for various medical conditions.

Adipose tissue-derived stem cells for veterinary use

An optical pattern-driven light induced dielectrophoresis (DEP) apparatus and separation methods are described which provide for the manipulation of particles or cells and selection based on traits correlated with the DEP response. Embodiments of the apparatus use DEP electric field patterns in combination with microfluidic laminar flows to measure response, separate, segregate and extract particles from heterogeneous mixtures according to the relative response of the particles to one or more DEP fields without damaging living cells. The preferred OET-DEP devices generally comprise a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a localized virtual electrode with a DEP electric field gradient of selected intensity along with input and a plurality of output fluidic channels. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The methods are particularly suited for selecting and extracting the best sperm and embryo candidates based on fitness for use with existing artificial reproduction procedures and excluding defective or non-viable gametes.

Methods and devices for sorting cells and other biological particulates

An optical pattern-driven light induced dielectrophoresis (DEP) apparatus and separation methods are described which provide for the manipulation of particles or cells and selection based on traits correlated with the DEP response. Embodiments of the apparatus use DEP electric field patterns in combination with microfluidic laminar flows to measure response, separate, segregate and extract particles from heterogeneous mixtures according to the relative response of the particles to one or more DEP fields without damaging living cells. The methods are particularly suited for selecting and extracting the best sperm and embryo candidates based on fitness for use with existing artificial reproduction procedures and excluding defective or non-viable gametes.

This invention relates generally to the field of urology. In particular, the invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder, which method comprises administering an effective amount of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), basic fibroblast growth factor (bFGF), or a functional derivative or fragment thereof, or a nucleic acid encoding said VEGF, BDNF or bFGF, or functional derivative or fragment thereof, or an agent that enhances production and/or erection or sexual arousal stimulating function of said VEGF or BDNF or bFGF to a mammal, wherein such prevention or treatment is desirable, thereby preventing or treating said male erectile dysfunction or female sexual arousal disorder in said mammal. Combinations, combinatorial methods and kits for preventing or treating male erectile dysfunction or female sexual arousal disorder are also provided.

Methods and compositions for preventing and treating male erectile dysfunction

Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful scaffolds which promote the regeneration of muscle tissue and aid in restoring muscle function. Due to their acellular nature, the grafts lack antigenicity. As a result, the acellular matrix grafts can be isolated from autographic, allographic or xenographic tissues.

Acellular matrix grafts of collagen and elastic fiber

The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of factors including vascular endothelial growth factor, brain-derived neurotrophic factor, basic fibroblast growth factor, neurotrophin-3, neurotrophin-4, or angiopoietin-1, wherein the factor is a full length protein or a nucleic acid encoding the factor, or a functional derivative or fragment thereof, or an agent that enhances production and/or male erection or female sexual arousal stimulating function of the factor(s). Combinations, kits, and combinatorial methods are also provided.

Methods and compositions for treating male erectile dysfunction

Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder

Acellular matrix grafts: preparation and use

The present invention provides a method of growing smooth muscle cells in a host with the purpose of maintaining natural cellular function by the function of smooth muscle tissue. In this method, smooth muscle cells are freed from isolated smooth muscle tissue then cultured and injected into the host in combination with an extracellular matrix.

Smooth muscle tissue formation in vivo using cultured smooth muscle

An electro-acupuncture system comprises a transmitter for emitting high frequency magnetic energy pulses and a receiver, sealed within an implantable 'thumb-tack' shaped device, for receiving and converting such pulses into stimulating pulses of current. The device comprises a head having an exposed ring-electrode (anode) secured therein and a needle-like electrode (cathode) having a proximal end secured in the head and a distal end adapted to pierce body tissue. The latter electrode comprises a metallic tube secured in the head and a metallic wire inserted through the tube to position and fix an exposed tip of the wire at a preselected location and depth in the body tissue, in accordance with method steps taught herein.

Growing community of inventors

Millbrae, CA, United States of America

Tom F Lue