Applera Corporation

Dh Technologies Development Pte. Ltd.

Mds Inc.

Mds Analytical Technologies, a Business Unit of Mds Inc.

Applied Biosystems, LLC

Mds Sciex

Tom Covey

Xinghua Guo

Andries P. Bruins

Andries Pieter Bruins

Bradley B Schneider

Erkin Nazarov

Andries P Bruins

A mass spectrometer system including a differential mobility spectrometer and a mass spectrometer at least partially sealed to, and in fluid communication, with, the differential mobility spectrometer, together with a related method, are provided. The mass spectrometer system can be operable to, and method can comprise, a) maintaining the differential mobility spectrometer at an internal operating pressure; b) providing ions to the differential mobility spectrometer; c) maintaining the mass spectrometer at a vacuum pressure lower than the internal operating pressure to draw a gas flow including the ions through the differential mobility spectrometer and into the vacuum chamber; and, d) modifying the gas flow between the differential mobility spectrometer and the mass spectrometer to change a gas flow rate through the differential mobility spectrometer.

Method and system for vacuum driven differential mobility spectrometer/mass spectrometer interface with adjustable resolution and selectivity

In various aspects, the present teachings provide systems and methods for reducing chemical noise in a mass spectrometry instrument that use a neutral chemical reagent and one or more mass filters to reduce interfering chemical background ion signals that are generated by ionization sources of mass spectrometers. In various embodiments, the neutral chemical reagent belongs to the class of organic chemical species containing a disulfide functionality.

Chemical noise reduction for mass spectrometry

Growing community of inventors

Richmond Hill, Canada

Tom Covey