Pall Life Sciences Belgium Bvba

Atmi Bvba

Pall Technology UK Limited

Pall Life Sciences Belgium

Tom Claes

Steven Vanhamel

Jean-Pascal Zambaux

Christophe Braet

Florence Bosco

Nicolas Havelange

Jose Castillo

A disposable material processing apparatus, useable as a bioreactor or fermenter, includes a hollow tank () and a mixing paddle () disposed within the interior of the tank and adapted to mix contents therein. The paddle may be isolated within a flexible sleeve (). Various functional elements, such as a sparger, sensor, material extraction conduit, material addition conduit, and/or heat exchange element may be provided, and optionally arranged to travel with the paddle within the tank interior. Baffles may protrude into a mixing tank to enhance mixing. A tank and/or sleeve may comprise polymeric film materials.

Disposable bioreactor

A mixing apparatus including a kinetic energy source, a mixing tank, a pivot guide, and transfer shaft is used to drive a mixing paddle through a circular path within a tank without substantial shaft rotation. Sleeved and sleeveless mixing paddles are provided in combination with sealable mixing tanks. A volumetric compensation system responsive to tank wall deflection is used to maintain the internal volume of a mixing tank within predetermined limits. One mixing apparatus includes multiple mixing shafts and paddles coupled to at least one kinetic energy source. Methods for fabricating sleeved paddle-containing mixing apparatuses are further provided.

Systems and devices for mixing substances and methods of making same

A system providing a sterile connection between a sensor probe and a fluid processing apparatus (e.g., a bioreactor) includes a first probe receiving element mountable to the fluid processing apparatus and a second probe receiving element having a gas-permeable contaminant barrier material and coupleable to the first probe receiving element. A sensor probe may be mounted to the second probe receiving element, with the combination being sterilized with a sterilant gas such as steam. Following such sterilization, connection between the first and second probe receiving elements is made through matable sterile couplings, and the probe is insertable through the coupled receiving elements to a position in fluid contact with the interior of the fluid processing apparatus.

Bioreactor probe connection system

Growing community of inventors

Bilzen., Belgium

Tom Claes