The University of Arizona

Tom C Tsang

David T Harris

Evan M Hersh

Eugene W Gerner

Xianghui He

Linda C Meade-Tollin

Brian L Pipes

Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell. Antibodies against ubiquitin are shown to inhibit tumor cell migration.

Stem cell fusion model of carcinogenesis

Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell (FIG.). Antibodies against ubiquitin are shown to inhibit tumor cell migration.

Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.

Growing community of inventors

Tucson, AZ, United States of America

Tom C Tsang