Other

Tom Beugeling

Adriaan Bantjes

Waander Riethorst

Bondewyn W Konig

Willem G Van Aken

Marcelinus P Te Booy

This invention relates to a process and to absorbent material for isolating coagulation factors, including FVIII and vWF, from the example blood plasma and plasma products by means of liquid chromatography. The adsorbent material comprises a polymeric carrier to which amino groups are linked as ligands through spacers. The spacers have a chain length of at least 6 atoms and contain at least one hydrophilic link within the chain. The spacers preferably have the formula --(CH.sub.2).sub.m --CO--NH--(CH.sub.2).sub.n -- wherein m and n each represent an integer of 1-6 and m+n is at least 4. The spacers are preferably linked to the carrier through --CO--NH-- groups. The ligand density in the absorbent material is preferably higher than 30 umoles/ml of swollen matrix.

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Enschede, Netherlands

Tom Beugeling