Sunnybrook Research Institute

St. Michael's Hospital.

Unity Health Toronto

Baycrest Centre for Geriatric Care

Providence St. Joseph's and St. Michael's Healthcare

Tom Andreas Schweizer

Simon James Graham

Fred Tam

Stephen C Strother

Xiao-Yan Wen

R Loch Macdonald

Mahta Karimpoor

Melanie Anne Morrison

Andrew Baker

Sunit Das

Marco Garavaglia

Systems and methods of are disclosed for providing visual feedback to a subject during magnetic resonance imaging, where the visual feedback is associated with input provided by the subject to a magnetic resonance compatible touch panel. A video camera is employed to record video images of the interaction between the subject and the touch panel, and the video images are processed to generate a real-time video signal including a rendering of the input provided to the touch panel and the interaction between the subject's hands and the touch panel. The real-time video signal is provided to the subject as visual feedback, and is displayed within a time duration that is sufficiently fast to avoid the detection of the visual feedback as an error signal with the subject's brain in relation to the sense of proprioception. A measurement of the force applied to the touch panel by the subject may be recorded and employed when rendering the real-time video. The systems and methods may be employed for a wide range of diagnostic and therapeutic procedures involving magnetic resonance imaging.

Systems and methods for providing visual feedback of touch panel input during magnetic resonance imaging

Systems and methods are provided for performing an intraoperative assessment of brain function based on input that is obtained using a touch panel device, in response to a task, and in the presence of an intervention that is applied to a selected region of the brain. The intervention may be stimulation of the selected region of the brain, such as direct cortical stimulation. In some embodiments, a measure is determined based on the input received from the touch panel. The measure may be a performance measure, related to the performance of the task, and/or a functional measure, associated with an inferred function of the selected region of the brain. In some embodiments, an image of the brain that is registered to an intraoperative reference frame may be annotated or otherwise modified within the selected region based on the measure.

System and method for intraoperative characterization of brain function using input from a touch panel device

The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages.

Small molecule therapeutic compounds that reduce the incidence of intracerebral hemorrhage and brain microhemorrhages

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Oakville, Canada

Tom Andreas Schweizer