Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Kyowa Hakko Kogyo K.k.

Tokuyuki Kuroda

Makoto Morimoto

Tadashi Ashizawa

Eiji Hayakawa

Nobuhiro Nakamizo

Kenji Muto

Koji Hisamura

Masashi Nakakura

Hideo Ueno

Yutaka Ohsawa

Tohru Sugaya

Akira Karasawa

Koji Yamada

Shunji Ichikawa

Katsuichi Shuto

Ikuo Matsukuma

Minoru Watanabe

Tamotsu Hashimoto

Tomoaki Masada

Toru Sugaya

Yasushi Shida

Yasuhiko Ueno

Yuji Ueno

Mitsuru Terajima

Hirotake Naganuma

Method for stabilizing compound DX-52-1 and lyophilized composition

Method for stabilizing duocarmycin derivatives

A motilin preparation in the form of a rectal suppository containing motilin together with a pH controller capable of adjusting the pH value of the intrarectal fluid to 8.0 to 10.0, which is highly useful as a rectal suppository.

Rectal motilin preparation

Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.

Mitomycin compounds having useful anti-tumor activity

Mitomycin derivatives having potent antitumor activity having the formula: ##STR1## wherein A is ON--or R.sub.4 N.dbd.N--[wherein R.sub.4 is selected from ##STR2## and optionally substituted heterocyclic groups (wherein R.sub.5 and R.sub.8 are each independently selected from hydrogen, lower alkyl and lower cycloalkyl; R.sub.6 is selected from hydrogen, halogen, hydroxy, lower alkoxy, amino and nitro; R.sub.7 is selected from lower alkyl and lower cycloalkyl; and X is selected from oxygen, sulphur and imino)];

Mitomycin derivatives as antileukemia agents

Mitomycin derivatives having potent antitumour activity have the formula: ##STR1## wherein R represents lower alkyl, cycloalkyl or unsubstituted or substituted aralkyl;

The compound of the formula ##STR1## is disclosed to have a less rapid decrease in blood pressure in its use as an antihypertensive.

1-benzyl-3,5-dimethyl-4-piperdyl ester of a Hantzsch dihydropyridine

An optical isomer having an optical rotation degree of (+) from among (.+-.)-.alpha.-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dica rboxylic acid-3-(1-benzyl-3-piperidyl) ester-5-methyl ester, the hydrochloride of which has melting points ranging from 196.degree. to 202.degree. C.; or a salt thereof is described as being suitable for use in a pharmaceutical composition having hypotensive activity.

1,4-Dihydropyridine derivatives

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Shizuoka, Japan

Tokuyuki Kuroda