Osaka University

Nard Institute, Ltd.

Tokutaro Ogata

Hidekazu Nakao

Yoshikatsu Kanai

Shushi Nagamori

Junichi Hoshino

Naoki Miyashita

Yoshikazu Yamamoto

A compound having a structure represented by the general formula (I): (wherein n is 0 or 1;Rrepresents a hydrogen atom (only if n=0), a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, an optionally substituted amino group, an optionally substituted phenyl group, a C1-C6 alkylthio group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group or a C7-C12 aralkyloxy group;Rrepresents &#x2014;(CH)&#x2014;[O(CH)]&#x2014;X (wherein X is a halogen atom, p is an integer of 1 to 6, q is an integer of 1 to 4, and r is an integer of 0 to 4);Rrepresents a hydrogen atom, a C1-C6 alkyl group, a C7-C16 aralkyl group or a C6-C14 aryl group; andRrepresents a hydrogen atom or a C1-C6 alkyl group), or a pharmaceutically acceptable salt thereof excels FAMT in terms of the tendency to accumulate intensively in cancer, the affinity for LAT1 and the selectivity for cancer, and can be labeled using an automated synthesizer in clinical settings, and therefore is useful as a highly versatile PET imaging agent.

Aromatic amino acid derivative and positron emission topography (PET) probe using the same

The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MTreceptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I): wherein Ris a protective group of the amino group and the like; Ris a protective group of the carboxy group and the like; Ris a hydrogen atom and the like; Ris a halogen atom and the like; A is &#x2014;(CH)&#x2014;[Z(CH)]&#x2014;; X is a leaving group.

Tyrosine derivative and method for producing tyrosine derivative

Growing community of inventors

Hyogo, Japan

Tokutaro Ogata