Fujirebio Kabushiki Kaisha

Fujizoki Pharmaceutical Co., Ltd.

Armour Pharma Gmbh

Tokusuke Kimura

Fumio Kurosu

Toshitsugu Inouchi

Jurgen-Dietrich Friedrich-Fiechtl

Masana Komatsu

Bernhard Kerner

Jurgen Holzapfel

Martin Puschmann

An improved process for the preparation of gamma globulin suitable for intravenous administration comprises dissolving gamma globulin precipitated from blood or blood products in a solution, separating non-dissolved precipitate from the solution, adding polyethylene glycol to the separated solution, separating precipitate from the polyethylene glycol solution, increasing the polyethylene glycol concentration in the solution, separating precipitated purified gamma globulin from the higher concentrated polyethylene glycol solution, dissolving the purified gamma globulin in a solution suitable for intravenous administration, which process is improved by dissolving the gamma globulin precipitated from blood in a solution having a neutral pH, adding polyethylene glycol in the first step to a concentration of 4.0-5.5% by weight, and increasing the polyethylene glycol concentration in the second step to at least 9% but not more than 16% by weight, and by adding a buffer to the solution just prior to adding the polyethylene glycol in one of the two polyethylene glycol addition steps.

Process for preparing gamma globulin suitable for intravenous

A method of preparing gamma globulin suitable for intravenous administration comprising a first step of treating a supernatant liquid separated from human blood plasma with ethanol under conditions of a pH of 5.5 to 6.5, an ethanol concentration of 30 to 35%, and a protein concentration of 1 to 2% by weight.

Method of preparing gamma globulin suitable for intravenous

The method of preparing immunoglobulin (IgG) suitable for intravenous administration comprising the fractionation of Cohn Plasma Fraction II with polyethylene glycol having a molecular weight of 4000 at predetermined concentrations and under selected pH conditions.

Method of preparing immunoglobulin suitable for intravenous

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Tokyo, Japan

Tokusuke Kimura