Mitsubishi Pharma Corporation

Mitsubishi Tanabe Pharma Corporation

Sanofi-aventis

Welfide Corporation

Tokushi Hanano

Kunitomo Adachi

Koji Teshima

Yoshiyuki Aoki

Tetsuro Fujita

Kenji Fukunaga

Yukio Hoshino

Toshiyuki Kohara

Masahiro Okuyama

Masanori Minoguchi

Yoshihiro Usui

Hideki Horiuchi

Masatake Fujimura

Hiroshi Morimoto

Shin-ichiro Ono

Hirotaka Okabe

Masao Hisadome

Masakazu Nakano

Shin-Ichiro Ono

Provided is an ORL-1 receptor agonist having improved bioavailability based on superior metabolic stability and strong and high selectivity, as compared to conventional compounds. A compound represented by the formula (I) wherein each symbol is as defined in the claims.

Benzimidazole compound and pharmaceutical use thereof

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof useful as a tau protein kinase 1 inhibitor: wherein X represents CH or nitrogen atom; Rrepresents a C?1#191-C?12#191 alkyl group which may be substituted; Rrepresents a C?1#191-C?8#191 alkyl group which may be substituted, a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom, and nitrogen atom, and having 5 to 10 ring-constituting atoms in total. 

3-substituted-4-pyrimidone derivatives

The present invention relates to a compound of the general formulawherein R, R, Rand Rare each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.

2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same

The present invention provides dihydropyrazolopyridine compounds represented by the formula (I):wherein each symbol is as defined in the specification, optically active forms thereof, and pharmaceutically acceptable salts thereof and hydrates thereof. The compounds of the present invention show a selective and strong inhibitory activity on glycogen synthase kinase-3 beta (GSK-3&#x3b2;), and are useful as medicaments for prevention and/or treatment of diabetes, diabetic complications and neurodegenerative diseases or as immunopotentiators.

Dihydropyrazolopyridine compounds and pharmaceutical use thereof

Piperazine compounds and medicinal use thereof

The present invention relates to a compound of the general formula

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Tokyo, Japan

Tokushi Hanano