Nippon Kayaku Kabushiki Kaisha

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Tokuji Nakatani

Akio Fujii

Katsutoshi Takahashi

Hamao Umezawa

Yasuhiko Muraoka

Takeyo Fukuoka

Hisao Ekimoto

Masanobu Suzuki

Takao Izawa

This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (I):

Selenium oxy chloride-pyridine or bipyridine complexes

Disclosed is a 3-(4'-aminobutylamino) propylaminobleomycin having low pulmonary toxicity, which expressed by the following general formula

Novel 3-(4'-aminobutylamino) propylaminobleomycin derivatives

An aminopropylaminobleomycin represented by the following formula or a salt thereof, which is minimized in side effects such as pulmonary toxicity:

Aminopropylaminobleomycin derivatives and process for preparation thereof

A promising carcinostatic (amido)N-substituted bleomycin represented by the following formula, or a salt thereof and a process for the preparation thereof: ##STR1## wherein BM represents a moiety of bleomycin skeleton; X represents an alkyl of 1 to 18 carbon atoms, an aminoalkyl of 1 to 12 carbon atoms, a lower alkyl having a halogen, phenyl indolyl, 5- or 6-membered heterocyclic group, or (lower)alkylamino (the alkyl group may have a substituent group) as a substituent, naphthyl, thiazolyl, or N-phenyl(lower)alkylpiperazinyl; and R represents a terminal amino residue of the bleomycin.

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Saitama, Japan

Tokuji Nakatani