Hamamatsu-photonics K.k.

Tokio Takagi

Mitsuo Hiramatsu

Gen Takebe

Tomonori Kawakami

Kazuue Fujita

Tatsuo Dougakiuchi

Naota Akikusa

A microparticle dispersion liquid manufacturing apparatusincludes a controller, a light source, an irradiation optical system, and a container. A solid objectis contained in and a solventis injected into an interior of the containerto enable attainment of a state where the solid objectis in contact with the solvent. The light sourcerepeatedly outputs pulsed light. By repeatedly irradiating the solventwith the pulsed light from the light source, expansion and contraction of the solventis made to occur repeatedly at the irradiated portion, thereby generating a pressure wave in the solvent, and the pressure wave is made to act on the solid objectto finely pulverize the solid objectand thereby manufacture a microparticle dispersion liquid in which microparticles are dispersed in the solvent. A microparticle dispersion liquid manufacturing method and manufacturing apparatus are thereby realized by which both suppression of impurity formation and an increase in efficiency of microparticle formation can be achieved readily.

Fine-particle dispersion liquid manufacturing method and fine-particle dispersion liquid manufacturing apparatus

A method and an apparatus enabling manufacture of a microparticle dispersion liquid at high efficiency in a short time while suppressing drug degradation, etc., are provided. In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent in a container. In a fixing step following the dissolving step, the organic solvent, contained in a solution, is eliminated by evaporation, a pellet-form residueis obtained by the organic solvent elimination, and the residueis fixed on an inner wall of the container. In a water injecting step following the fixing step, wateris injected into an interior of the container. In an irradiating step following the water injecting step, laser light, emitted from a laser light source, is irradiated on the residuefixed on the inner wall of the container, and the residueis thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured. The microparticles contain the poorly soluble drug and the dispersion stabilizer.

Microparticles, microparticle dispersion and method and apparatus for producing the same

In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residuesare obtained by the organic solvent removal, and the residuesare fixed on respective bottom surfaces of a plurality of locations of a container. In a water injecting step, wateris injected into each of a plurality of recessesof the container. In an irradiating step, laser light L, emitted from a light irradiating unit, is irradiated simultaneously or successively on the residuesfixed on the respective bottom surfaces of the recessesof the container, and the residuesare thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured.

Microparticle dispersion liquid manufacturing method and microparticle dispersion liquid manufacturing apparatus

A to-be-treated body, which contains raw material particlesof a substance and with which a solventof a to-be-treated liquidis made solid, is used, and a laser light source, which supplies a laser light of a predetermined wavelength to a treatment chamberthat contains the to-be-treated body, is provided to arrange a production apparatusA. The laser light from the laser light sourceis illuminated onto the to-be-treated body to microparticulate the substance in solvent. As the to-be-treated body of solid form, a solidified body, with which wateris solidified by a cooling deviceand the solidified state is maintained by a thermally insulating layer, may be used. Or, as the to-be-treated body, a gel body, with which the solvent is gelled, may be used. The substance can thereby microparticulated efficiently by photo-pulverization.

Microparticles, microparticle production method, and microparticle production apparatus

A production apparatus which includes: a treatment chamber, containing a to-be-treated liquid, made up of water, which is a solvent, and raw material particles of a substance; a laser light source, illuminating laser light for microparticulation onto the to-be-treated liquid; an ultrasonic transducer, irradiating ultrasonic waves for preventing aggregation of microparticles; and a controlling device, controlling the laser light illumination by the laser light source and the ultrasonic wave irradiation by the ultrasonic transducer. A vibration amplitude of the treatment chamber is monitored by means of a microphone and a vibration amplitude measuring device to set the frequency of the ultrasonic waves to a resonance vibration frequency. A microparticle production method and production apparatus that enable substances to be microparticulated efficiently by photo-pulverization, and microparticles are thus realized.

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Hamamatsu, Japan

Tokio Takagi