Mitsubishi Tanabe Pharma Corporation

Tohru Takebe

Tetsuo Yamaguchi

Hideki Ushirogochi

Tatsuyuki Takahashi

Hiroyuki Kawanishi

A compound of the formula: wherein ring X is benzene or pyridine; Ris substituted alkyl; Ris optionally substituted aryl or optionally substituted heterocyclic group; Ris hydrogen or alkyl; Ris hydrogen, halogen or alkyl; Ris hydrogen or alkyl; Rand Rare the same or different and each hydrogen or halogen, or a pharmaceutically acceptable salt thereof, which is useful as Iblocker effective for preventing or treating cardiac arrhythmia such as atrial fibrillation.

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Osaka, Japan

Tohru Takebe