National Institute of Advanced Industrial Science and Technology

Kabushiki Kaisha Yaskawa Denki

Nano Solution, Inc.

Other

Fujifilm Corporation

Fujifilm Toyama Chemical Co., Ltd.

National Center for Geriatrics and Gerontology

Tecnisco Limited

Kyoto Pharmaceutical University

Tohru Natsume

Kenji Matsukuma

Toshiaki Isobe

Sakae Yamaguchi

Hiroshi Nakayama

Hiroyuki Kimura

Tadashi Tanaka

Yoshio Yamauchi

Kentaro Furuya

Masataka Fujino

Kazuo Shinya

Keiko Makita

Tomoya Inoue

Shungo Adachi

Kazunori Saeki

Houkichi Yoshioka

Takahisa Yoshimura

Takayuki Doi

Ken Watanabe

Yoshi Yamauchi

Katsuo Mogi

A protocol created in such a format that a series of operations for process targets in the fields of engineering related to living organisms are executable by a robotis acquired (S). The robotis controlled to implement the operations for the process targets according to the protocol (S). In order to modify the protocol after the implementation of the operations, modification information on at least one action among basic actions which serve as bases for implementing the operations and is performed on an instrument used by the robotin the operations, and complementary actions which complement the basic actions is acquired (S). The robotis controlled to produce processed products from the process targets by using the protocol modified based on the modification information (S).

Processed product production apparatus, processed product production method, computer-readable storage medium, and processed product production system

A protocol created in such a format that a series of operations in cell culture are executable by a robotis acquired (S1). The robotis controlled to implement the operations according to the protocol (S2). In order to modify the protocol after the implementation of the operations, modification information on at least one action among basic actions which serve as bases for implementing the operations and is performed on an instrument used by the robotin the operations, and complementary actions which complement the basic actions is acquired (S5). The robotis controlled to produce cells by using the protocol modified based on the modification information (S7).

Cell production apparatus, cell production method, computer-readable storage medium, and cell production system

A method for producing a liquid reaction mixture containing a radioisotope, in particular, a radioactive composition, minimizes device contamination with radioactive substances and increase speed and accuracy with which droplets are mixed. The method for producing a radioactive composition includes placing at least one first droplet Lcontaining a radionuclide and at least one second droplet Lcontaining a labeling substance on at least two respective dimplesamong dimpleson a front surfaceof an insulating layerof a liquid manipulation device, and obtaining a liquid mixture M by using a change in electrostatic force caused by changing voltage applied to the electrodesto thereby cause a relative movement between the at least one first droplet Land the at least one second droplet Lso that the at least one first droplet Land the at least one second droplet Lare mixed together at any one dimple among the dimples

Method for producing radioactive composition

It is an object of the present invention to provide an antitumor agent, which is further excellent as a treatment agent used in the prevention and/or therapy of tumor associated with a bromodomain, and also to provide a bromodomain inhibitor, which is useful as a treatment agent for diseases or states associated with a bromodomain. An antitumor agent and a bromodomain inhibitor, comprising a compound represented by the following formula, have an excellent bromodomain inhibitory activity and are useful as treatment agents in the prevention and/or therapy of tumor associated with a bromodomain, and the like: 

Antitumor agent and bromodomain inhibitor

The present invention provides a water-cooled heat sink having an integrated structure, and having inside a precise, freely formed flow path, the water-cooled heat sink being produced without using a technique for pasting a plurality of metal sheets. In a water-cooled heat sink, a formed bodyis provided outwardly, a flow pathfor passage of a liquid is formed inwardly of the formed body, and an inletand an outletfor the liquid, which communicate with the flow path, are formed in the main body of the heat sink. The entire formed bodyof the heat sinkis integrally formed by thick coating layers applied by electroplating, and has no joints.

Method of producing body having flow path formed therein, and body having flow path formed therein

Disclosed is a labeling substance capable of reversibly immobilizing (reversible detachment) to a solid surface and to reliably and accurately identify a target biological substance interacting with a probe substance bound to the labeling substance. A chimeric compound is provided, which includes a labeling substance L including (1) an organic compound S with a chemical structure capable of binding to a probe substance P, which can interact with a biological substance B and (2) a peptide bound to the organic compound S and specifically recognized by an antibody A, peptide and a probe substance P at least except a peptide or protein. In addition, a method for preparing the labeling substance L and a method for capturing, structurally analyzing and/or identifying the biological substance using the labeling substance L are provided.

Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance

A method for screening therapeutic agents for disuse muscular atrophy is provided that includes the steps of interacting a selected protein with a polyubiquitin chain in the presence of a candidate therapeutic agent, and determining the effect of the candidate on the binding strength between the protein and the polyubiquitin chain. The effect may be observed by color development on a substrate when the steps are carried out by way of an enzyme-linked immunosorbent assay, or by direct observation via NMR spectroscopy, X-ray crystal analysis, electron microscopy or surface plasmon resonance.

Method for screening therapeutic agents for disuse muscular atrophy using interaction between selected proteins and a polyubiquitin chain

The invention aims to provide a highly accurate automatic biopolymer determination technique utilizing mass spectrometry whereby calibration prior to measurement or the addition of an internal standard to a sample can be eliminated. The biopolymer automatic identifying method of the invention comprises: retrieving a candidate molecule by matching an observed mass value X obtained by mass spectrometry with a predetermined database; selecting an arbitrary number of candidate molecules with high similarity scores; calibrating the observed mass value X using the candidate molecule as an internal standard; calculating relative error Ec between a calibrated mass value Xc and a theoretical mass value M of the candidate molecule; determining the standard deviation Sof the relative error; determining a tolerance Tc of database search from the standard deviation S; and repeating a database search based on the tolerance Tc.

Biopolymer automatic identifying method

The present invention aims to provide a liquid chromatograph, an analysis system, and a gradient elution method, which are designed to permit a gradient change of eluent with higher precision and also permit a high sensitive detection or analysis. For attaining the object, there are provided: a liquid chromatograph having at least a liquid-feeding means for flowing an eluent E at a predetermined flow rate, a sample-pouring means for pouring a sample Sm into the eluent E, and a separation-column means for separating a solute So contained in the sample Sm into components, comprising an eluent-selecting means for forming branched flow paths having predetermined volumes by dividing a flow path of the eluent E fed from the liquid-feeding means, temporally storing eluents E, E, and soon in the branched flow paths, and pouring the sample Sm into the selected eluents E, E, and so on, and means for carrying out a gradient elution of a solute So; an analysis system comprising a mass spectrometer connected to the liquid chromatograph, and a gradient-elution method using the liquid chromatograph.

Liquid chromatograph and analysis system

A problem is to provide a microspray column capable of increasing the ionization efficiency, and a high sensitive mass spectrometer and a mass spectrometric method using such a microspray column. For solving this problem, we provide a column for introducing a sample in an ionization source of a mass spectrometer (ESI/MS) being designed to ionize a sample molecule with electrospray and introduce it into an analyzer, has structural features of: (1) 0.5 &#x3bc;m or less in an inner diameter of a tip opening of the column; (2) 0.5 &#x3bc;m or more and 5 &#x3bc;m or less in a particle size of a column filler; and (3) fritless, a microspray column having the above (1) to (3), a mass spectrometer having such a microspray column in an ionization source, and a mass spectrometric method capable of performing a nonoflow electrospray with the microspray column.

Microspray column, mass spectrometer, and mass spectrometry

Growing community of inventors

Tokyo, Japan

Tohru Natsume