Shin-etsu Chemical Co., Ltd.

The Institute of Physical and Chemical Research

Shin-estu Chemical Co., Ltd.

Tohru Chiba

Hiroyasu Kokubo

Hiroaki Muto

Kazumasa Maruyama

Yoshiro Onda

Fujio Sekigawa

Minoru Takamizawa

Jun Watanabe

Tatsushi Kaneko

Isao Endo

Kazuhisa Hayakawa

Sakae Obara

Yuichi Nishiyama

Noboru Hoshi

Izumi Saitoh

Soji Tanioka

Ken Yahata

Kaori Ikeda

Hiroshi Miyoshi

Shin-Ichiro Nakamura

Yasuyoshi Koumoto

Tadasu Nunoue

Sumiko Mizuno

Okmi Park

A peptide having an amino acid sequence represented by the following formula: Ser-Thr-Lys-Glu-Gly-Asp-Ser-Ser-Asn-Thr-Gly-Ala-Gly-Lys-Ala-Leu-Thr-Gly-Le u-Ser-Thr-Gly specifically reacts with antibodies against human parvovirus B19. Therefore, this peptide can be used in agents for detecting antibodies against human parvovirus B19 and in methods for detecting antibodies against human parvovirus B19.

Epitope-related peptides of human parvovirus

According to the method for preparing chitosan of the present invention, chitosan is prepared by inoculating a filamentous fungi belonging to the family Mucoraceae into a culture medium for pre-cultivation containing yeast extract, malt extract, peptone, glucose and magnesium sulfate to perform pre-cultivation and then inoculating the pre-culture into a culture medium for main-cultivation having a composition essentially identical to that of the medium for pre-cultivation to perform the main-cultivation. Particularly preferred filamentous fungi belonging to the family Mucoraceae is Absidia coerulea. According to the method for preparing chitosan through the cultivation of microorganisms, chitosan exhibiting uniform quality can efficiently be produced and the method does not adversely affect the circumferential environment.

Method for preparing chitosan

A novel endermic medicament having a consistency of a gel is proposed which is formulated, as a gel base, with non-ionic water-soluble cellulose ether, e.g., methyl cellulose and hydroxypropyl methyl cellulose, modified with a modification agent containing, in the molecule, an alkyl group having 6 to 26 carbon atoms and a functional group having reactivity with the hydroxyl group in the cellulose ether, e.g., stearyl glycidyl ether, decyl glycidyl ether and cetyl epoxide. The endermic medicament formulated with the modified cellulose ether is stable by virtue of the very little interaction between the active ingredients and the gel base and also can exhibit high percutaneous absorptivity of the active ingredients through the human skin.

Endermic medicament with a gel base

A cement composition for extrusion which is produced by incorporating, into cement mortar, 3 to 15 weight % of crushed pulp fiber, 0.2 to 1 weight % of at least one member selected from an alkylcellulose and a hydroxyalkylalkyllcellulose, and a 2% water solution having a viscosity of 80,000 cps or more allows for reduced production costs by reducing the loads of the binder material using a pulp fiber without carcinogenicitic asbestos fiber. Furthermore, it allows for excellent extrudability and provides the moldings with workability such as nailing and sawing.

Cement composition for extrusion

Film coated pharmaceutical preparations, which are prepared by overlaying to the outer surface of pharmaceutical preparations, a coating layer comprising at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethylethyl cellulose and cellulose acetate phthalate, are irradiated with light including ultraviolet rays. Whereby film coated pharmaceutical preparations, the coating layer surface of which are excellent in whiteness, are prepared. Moreover, as a content of a white pigment in corporated into the coating layer of such preparations may be reduced, the stability of such preparations can be enhanced without impairing the strength of the coating layer.

Method for preparing film coated pharmaceutical preparations and method

Method for the preparation of coated solid medicament form

In place of gelatin conventionally used as a material for shaping hard medicinal capsules, the invention proposes a hard capsule for medicinal use shaped of a polymer blend of a water-soluble cellulose ether, e.g., alkyl cellulose, hydroxyalkyl cellulose and alkyl hydroxyalkyl cellulose, and a polyvinyl alcohol in a weight ratio of 70:30 to 98:2. The inventive hard medicinal capsules have remarkably low permeability to oxygen and moisture with little influences on the medicament contained therein along with sufficiently high mechanical strengths and are much more stable than conventional gelatin-made capsules against the influences of the ambient conditions, such as, the crack formation unavoidable in a gelatin-made hard capsule when it is kept under an extremely low humidity.

Hard medicinal capsule

An electroluminescent device of the dispersion type exhibiting high brightness of electroluminescence and having excellent heat resistance and flexibility, and usable as a backlighting unit for liquid crystal displays and as a plane light-emitting body, can be prepared by using, as the matrix material of the particulate electroluminescent material, a specific cyanoalkyl group-containing organopolysiloxane represented by the average unit formula R.sup.1.sub.a R.sup.2.sub.b SiO.sub.(4-a-b)/2, in which R.sup.1 is a cyanoalkyl group having 3 to 5 carbon atoms, R.sup.2 is a monovalent hydrocarbon group, a is 0.8 to 1.8 and b is 0 to 1.0 with the proviso that a+b is 1.1 to 1.98.

Electroluminescent composition containing organopolysiloxane and

The dielectric polymeric film in the inventive film capacitor is formed from a cyanoalkyl-containing organopolysiloxane represented by the average unit formula

Film capacitor

Instead of using a uniform aqueous solution of a water-soluble cellulose ether as a coating liquid of solid medicament forms, e.g., granules and tablets, to form a film-forming layer, an aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, is used as a coating liquid at a temperature higher than the solubilization temperature, i.e. the critical point of the solubility behavior, followed by plasticization of the cellulose ether particles with water to cause fusion thereof. The coating liquid is freed from the limitation by the flowability even when the content of the cellulose ether is much higher than in the conventional solution-type coating liquid. In addition to the greatly decreased time taken for forming a coating layer in a desired coating amount, moreover, cellulose ethers having a high degree of polymerization, which cannot be used in the conventional method, can be used so that the resultant film-coating layer is much stronger than otherwise to provide a sustainedly releasing coating layer.

Method for the preparation of a coated solid medicament

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Niigata, Japan

Tohru Chiba