Array Biopharma Inc.

Todd T Romoff

George A Doherty

Laurence Edward Burgess

Adam Wade Cook

Kevin W Hunt

Christopher T Clark

Christopher Peter Corrette

Ganghyeok Kim

Robert Kirk Delisle

Robert Kirk DeLisle

Christopher P Corrette

Steven Armen Boyd

Kevin Ronald Condroski

Indrani W Gunawardana

Yvan Le Huerou

Allen A Thomas

Francis X Sullivan

Stephen S Gonzales

Provided herein are compounds of Formula I: in which A, A, W, L, G, R, R, R, Rand Rhave the meanings given in the specification, which are DP2 receptor modulators useful in the treatment of immunologic diseases.

6-substituted phenoxychroman carboxylic acid derivatives

Provided herein is a method of treating an allergic inflammatory disease selected from asthma, dermatitis, allergic rhinitis, urticaria, anaphylaxis, angioedemea, allergies, contact hypersensitivity, drug hypersensitivity, and allergic conjunctivitis in a mammal, comprising administering a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, to said mammal in need thereof, wherein A, A, W, L, G, R, R, R, Rand Rare as defined herein.

Compounds of Formula I: (I) in which A, A, R, R, R, Rand Rhave the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D(PGD). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13. 

7-phenoxychroman carboxylic acid derivatives

A compound having the formula: is useful in the preparation of compounds of Formula I.

Compounds of Formula (I): in which A, A, W, L, G, R, R, R, Rand Rhave the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases. 

The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R, R, R, R, R, R, R-R, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof. 

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Memphis, TN, United States of America

Todd T Romoff