Warner-lambert Company

Other

Warner Lambert LLC

Todd Robert Ryder

Lain-Yen Hu

Michael Francis Rafferty

Yuntao Song

Anthony Denver Sercel

Thomas C Malone

David T Connor

Bruce D Roth

David Juergen Wustrow

Suzanne Ross Kesten

Laszlo Nadasdi

Huangshu Lei

Laszlo Urge

Balazs G Szoke

Diego F Silva

The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, asthma, amyotropic lateral sclerosis, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.

Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers

The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases

Calcium channel blockers

Substituted diarylalkyl amides as calcium channel antagonists

The present invention provides compounds that block calcium channels having formula (I). The present invention also provides methods of using the compounds of formula (I) to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of formula (I).

Aniline derivatives as calcium channel blockers

The present invention provides compounds that block calcium channels having the Formula I shown below.

Heterocyclic substituted aniline calcium channel blockers

The present invention provides compounds that block calcium channels having the Formula I shown below. ##STR1## The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, asthma, amyotropic lateral sclerosis, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.

Substituted peptidylamine calcium channel blockers

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Ann Arbor, MI, United States of America

Todd Robert Ryder