Life Technologies Corporation

Thermo Fisher Scientific Geneart Gmbh

Lawrence Livermore National Security, LLC

Bristol-myers Squibb Compnay

Invitrogen Corporation

Genicon Sciences Corporation

Todd Peterson

Timothy Updyke

Joseph Amshey

Espir Kahatt

Michael Thacker

Alexander Khorlin

Timothy Powers

Lance Parsons

Daniel Bezdek

Kornelija Zgonc

Thomas Poehmerer

Axel Trefzer

Laurence Warden

Matthew A Coleman

Nicholas O Fischer

Craig D Blanchette

Farzad Haerizadeh

Evangelina E Yguerabide

Juan Yguerabide

Amy Rasley

Ewa Lis

Wen Chen

Xiquan Liang

Stephen W Mamber

Lyndon M Foster

Grace A McClure

Kimberly D Krampitz

Katie A Thompson

Jingfang Qian Cutrone

Federico Katzen

Lisa C Rupar

Korneija Zgonc

The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

High efficiency, small volume nucleic acid synthesis

A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and amajor outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.

MOMP telonanoparticles, and related compositions, methods and systems

The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.

Apparatus for and method of processing biological samples

The present invention provides compositions and methods for the genetic manipulation of Algal cells. The compositions and methods allow enhanced transfer of genetic material into Algal cells and the cloning and selection of genetically modified cells. Expression of proteins encoded by the genetic material will be enhanced by the methods and compositions of the invention.

Molecular biology tools for algal engineering

The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.

Methods for enhancing the dynamic range for specific detection of one or more analytes in assays using scattered-light detectable particle labels. The methods involve utilizing variations in detection technique and/or signal processing to extend the dynamic range to either or both of lower and higher concentrations.

Methods for providing extended dynamic range in analyte assays

A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain ofdesignatedWD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.

Tyrissamycin antibiotic

Growing community of inventors

Coronado, CA, United States of America

Todd Peterson