University of California

University of Washington

Todd O Yeates

David S Eisenberg

Edward M Marcotte

Matteo Pellegrini

Michael J Thompson

David Baker

Neil P King

William H Sheffler

Robert Damoiseaux

Jorge Torres

Phillip Nguyen

Yashes Srinivasan

Nithin Dharmaraj

Yen-Ting Lai

Andrew Liu

Silvia Senese

Justin Miller

Scott Taylor

Jennifer Padilla

Dan E McNamara

Chris Colovos

Yu-Chen Lo

Robert Grothe

Disclosed herein are self-assembling protein nanoparticles comprising passenger molecules of interest.

Self assembling protein nanoparticles as carrier molecules

This disclosure relates to methods of treating cancer (e.g., melanoma) with (MI-181).

Tubulin-binding compounds, compositions and uses related thereto

Methods and systems for computationally designing self-assembling polypeptides are disclosed. A representation of a docked configuration of a symmetric protein architecture can be determined by a computing device configured to computationally symmetrically dock representations of protein building blocks within a representation of a symmetric protein architecture, where symmetrically docking a representation of a particular protein building block can include determining a configuration of the protein building blocks in three-dimensional space within the symmetric protein architecture configured to generate interfaces between building blocks suitable for computational protein interface design. The amino acid sequence of the docked protein building blocks can be computationally modified to specify protein-protein interfaces between the plurality of protein building blocks that are energetically favorable to drive self-assembly of a protein that includes the modified amino acid sequence.

General method for designing self-assembling protein nanomaterials

A computational method system, and computer program are provided for inferring functional links from genome sequences. One method is based on the observation that some pairs of proteins A&prime; and B&prime; have homologs in another organism fused into a single protein chain AB. A trans-genome comparison of sequences can reveal these AB sequences, which are Rosetta Stone sequences because they decipher an interaction between A&prime; and B. Another method compares the genomic sequence of two or more organisms to create a phylogenetic profile for each protein indicating its presence or absence across all the genomes. The profile provides information regarding functional links between different families of proteins. In yet another method a combination of the above two methods is used to predict functional links.

Determining protein function and interaction from genome analysis

Novel fusion proteins capable of self-assembling into regular structures, as well as nucleic acids encoding the same, are provided. The subject fusion proteins comprise at least two oligomerization domains rigidly linked together, e.g. through an alpha helical linking group. Also provided are regular structures comprising a plurality of self-assembled fusion proteins of the subject invention, and methods for producing the same. The subject fusion proteins find use in the preparation of a variety of nanostructures, where such structures include: cages, shells, double-layer rings, two-dimensional layers, three-dimensional crystals, filaments, and tubes.

Self assembling proteins

Assigning protein functions by comparative genome analysis protein phylogenetic profiles

Rosetta stone method for detecting protein function and protein-protein interactions from genome sequences

Growing community of inventors

Los Angeles, CA, United States of America

Todd O Yeates