Zoetis Services LLC

Pfizer Corporation

Pharmacia & Upjohn Company

Todd M Maddux

Tomasz Respondek

Richard Andrew Ewin

Paul D Johnson

Rajendran Vairagoundar

Graham M Kyne

Mark R Cox

Michael B Tollefson

Timothy Lee Stuk

John Nicholas Freskos

Matthew James Graneto

David Louis Brown

Yvette M Fobian

Eric Jon Jacobsen

Margaret Lanahan Grapperhaus

Mark A Massa

Michele A Promo

Horng-Chih Huang

Andrew Simon Bell

Robert Owen Hughes

Timothy L Stuk

Dafydd Rhys Owen

Michael P Curtis

Brent V Mischke

Jaime L Masferrer

Michael John Palmer

E Jon Jacobsen

Susan M K Sheehan

David Graham Brown

Matthew W Bedore

John K Walker

Matthew William Mahoney

Grace Mary Wagner

John M Molyneaux

Jin Xie

Edgardo Alvira

Michelle Ann Schmidt

Jon Gordon Selbo

Christopher Phillips

Joseph B Moon

Imelda Hot

Richard Alan Vonder Embse

D Joseph Rogier, Jr

Mathew J Graneto

Kaliappan Iyanar

Kirby Ray Sample

Ronald Edward Seidel

Scott Santford Woodard

Steven E Heasley

Michele Ann Promo

Defined herein are immunomodulating Formula (1) compounds, wherein R, Rand W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating trifluoromethyl-aminal azalides

Defined herein are immunomodulating Formula (1) compounds, wherein R, R, R, R and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating or preventing an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, or pharmaceutically acceptable salt thereof; or use of said Formula (1) compound to prepare a medicament for treating or preventing an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating azalides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R,

Immunomodulating urea azalides

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R, R, R, R, L, and Lare as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1) compound.

Endoparasitic depsipeptides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R, Rand W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Described herein are pyrrolo[2,3-d]pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing these compounds, and methods for their preparation. 

Pyrrolo[2,3-D]pyrimidine compounds

The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.

Pyrazole derivatives as 5-LO-inhibitors

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R, R, Rand Rare as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

Pyridine [3,4-b] pyrazinones

The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein Ris F or H and to processes for the preparation of, intermediates used in the preparation of, compositions containing the uses of, such compounds. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular allergic and respiratory diseases, disorders and conditions.

Pyrazole analogs

Growing community of inventors

Kalamazoo, MI, United States of America

Todd M Maddux