University of California

Lumiphore, Inc.

Biophor Diagnostics, Inc.

Todd M Corneillie

Claude F Meares

Jide Xu

Nathaniel G Butlin

Kenneth N Raymond

Paul Whetstone

Carlito Bangeles Lebrilla

Sarah M Cheal

Susan Lee

Nicolas L Young

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

Luminescent macrocyclic lanthanide complexes

A method for performing time resolved homogeneous assays using a long-lifetime luminescent dye as a donor. A reaction well containing a sample portion, donor reagent, and acceptor reagent and a matrix well containing a sample portion and donor reagent are excited and the resulting emission from each is measured at a single wavelength associated with the acceptor. The measurement obtained from the matrix well is used to provide a correction for the measurement obtained from the reaction well. The sample may be a biological fluid such as an oral fluid.

Single-wavelength correction method for luminescent homogeneous biological assay

Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes

The present invention provides antibodies comprising an antigen recognition domain that specifically binds to a metal chelate: mutant antibodies comprising a reactive site not present in the wild-type of the antibody, wherein the reactive site is in a position proximate to or within the antigen recognition domain; and methods of using such antibodies to diagnose and treat disease.

Multi-functional antibodies

The present invention provides a mutant antibody comprising a reactive site not present in the wild-type of the antibody and a antigen recognition domain that specifically binds to a metal chelate, wherein the reactive site is in a position proximate to or within the antigen recognition domain.

The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.

Growing community of inventors

Campbell, CA, United States of America

Todd M Corneillie