Warsaw Orthopedic, Inc.

Osteotech, Inc.

Todd M Boyce

Lawrence A Shimp

John Winterbottom

David R Kaes

David Knaack

Guobao Wei

Albert Manrique

James L Russell

Nelson L Scarborough

Keyvan Behnam

Nanette Forsyth

John W Boyle

Daryl R Sybert

Cristy Richards

Erik O Martz

James Beisser

Deger C Tunc

Subhabrata Bhattacharyya

Robert Cohen

Daniel A Shimko

Mohamed Attawia

Randal R Betz

Benjamin T Reves

John W Morris

Jared T Wilsey

Michael F O'Brien

Mark P Daugherty

Jean T Edwards

Michele Diegmann

Alexis P Shelokov

Matthew M Morrison

Scott D Boden

Alexander R Vaccaro

Sigurd H Berven

Gretchen S Selders

Harvinder Sandhu

Munish Chandra Gupta

Larry Shimp

Samantha Salkeld

Stephen N Mercadante

Jinia Bhattacharya

Cristy J Richards

John M Winterbottom

A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

Methods and devices for delivering therapeutic materials to the intervertebral disc

An implant device for use in achieving spinal fusion, includes an implant having an implant body. The device includes a graded radiopacity calibration tool integrated with the implant body. The tool has a plurality of graded levels of radiopacity representative of a range of bone density parameter amounts. Each of the graded levels corresponds to a different bone density parameter amount. A method is provided that uses the device to determine a degree of one of bone maturity, strength, osteoporotic state, state of healing and state of degrading bone tissue based on a comparison of a bone at the site in the image and radiopacity correlated from a calibration standardized curve defined by the standard, with a range of grey levels representative of degrees of one of the bone maturity, the strength, the osteoporotic state, the state of healing and the state of degrading bone tissue.

Implant with graded radiopacity calibration feature

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Polyurethanes for osteoimplants

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.

Segmented delivery system

An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.

Injectable and moldable bone substitute materials

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Delivery system attachment

Delivery system

An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

Osteoinductive demineralized cancellous bone

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Matawan, NJ, United States of America

Todd M Boyce