University of Alberta

The Royal Institution for the Advancement of Learning / Mcgill University

Todd Lambert Lowary

Donald Christopher Sheppard

Susmita Sarkar

Benjamin Alfred William Rufus Ralph

Amira Ibrahim Aly Mohamed Khalil

Jillian Mary Buriak

Vincent Arthur Wright

Lori Jeanne West

Anne Margaret Cooper

Brian Daly

Mylvaganam Jeyakanthan

Peter John Meloncelli

It is provided novel anti-galactofuranose antibodies and their use for diagnosis of and/or treating aspergillosis, and for the design of chimeric antigen receptor T-cells, wherein single chain variable fragment of the antibodies, such as a heavy chain variable region or a light chain variable region, is fused via a spacer and a transmembrane domain to a signaling endodomain to generate an expression cassette that will be integrated into a T cell.

Anti-galactofuranose antibodies for detecting and treating aspergillosis

Described herein are methods and systems that can be used to induce immunologic tolerance to non-self antigens. The methods and systems comprise introducing a tolerogen comprising at least one immunogenic non-self antigen coupled to a carrier, wherein the immunogenic antigen can be a foreign or endogenous antigen or fragments thereof. The non-self antigen can be selected from the group consisting of carbohydrate antigens, full-length antigenic proteins, and fragments and combinations thereof, while the carrier can be selected from nanoparticles and stents. Tolerogen compositions are also provided and can be used to induce immunologic tolerance to non-self antigens. These methods, systems and compositions are particularly advantageous since they can be used to allow for the extension of the window of safety for immunologically-incompatible transplantations to patients who are growing past the age of infancy.

Methods and systems for inducing immunologic tolerance to non-self antigens

Growing community of inventors

Edmonton, Canada

Todd Lambert Lowary