Musculoskeletal Transplant Foundation

The Methodist Hospital

Focal Cool, LLC

Todd J Nilsen

Kevin Wu

Alison Ling

Elizabeth Ann Poyss

Evangelia Chnari

Yen-Chen Huang

Benjamin Schilling

Andrew Madans

Abigail Phipps

Thomas Tylutki

Moshe Laifenfeld

Aldona Jedrysiak Spiegel

Michael Locarno

Gregory P Adams

Kyle Stever

Antonio M Bunce

Ravi Ramachandran

Denise R Merrill

Jennifer Ellen Akers

Tissue graft retainer

Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises dilapidated, decellularized adipose tissue-derived matrix and dilapidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration. The methods for making the compositions may involve separation of first and second soft tissues from one another, followed by performing one or more treatments on the separated soft tissues, then combining the treated soft tissues and, optionally, performing one or more additional treatments on the combined soft tissues.

Acellular soft tissue-derived matrices and methods for preparing same

A tissue graft container is provided having an interior space and including a vent which allows fluid (liquid and vapor) to escape from the container during drying of the tissue graft. The vent may be one or more apertures, one or more elongated openings, or a combination thereof, through one or more components of the container. A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channels, and configured to removeably interconnect the first and second members in a closed configuration. The first and second pluralities of channels create a continuous interior space. The retainer further includes a vent, such as apertures, slits, etc., through one or both of the first and second retainers, for allowing moisture to escape from the retainer during the drying of a tissue graft contained within the continuous interior space of the retainer.

Packaging system for tissue grafts

A cutting device is provided having multiple evenly-spaced cutting blades and which is useful for producing tissue forms comprising membranous tissue fragments which are relatively uniformly sized and shaped. The present invention also relates to methods for using the cutter device to quickly and efficiently produce such tissue forms which are useful as grafts and can be flowable and easily passable through a luer-slip tip syringe or needle.

Multi-blade cutting device

A dermal tissue allograft includes a dermal matrix having a profile including first and second vertices, a first imaginary axis extending between the first and second vertices, a first peripheral edge extending along a continuous path from the first vertex to the second vertex on a first side of the first imaginary axis, and a second peripheral edge extending along a continuous path from the first vertex to the second vertex on a second side of the first imaginary axis. The first peripheral edge includes an apogee, a convex portion, and a concave portion. The convex and concave portions meet at a transition point located on the first peripheral edge between its apogee and the second vertex. The second peripheral edge includes an apogee and is convex. The second perpendicular distance is greater than the first perpendicular distance. The dermal matrix has a substantially uniform thickness across its profile.

Asymmetric tissue graft

Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration. The methods for making the compositions may involve separation of first and second soft tissues from one another, followed by performing one or more treatments on the separated soft tissues, then combining the treated soft tissues and, optionally, performing one or more additional treatments on the combined soft tissues.

A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channel sidewalls that define first and second pluralities of channels, and first and second engagement means configured to removeably interconnect the first and second members. The first and second pluralities of channel sidewalls are configured to create a continuous interior space between the first and second members. A tissue graft, such as a cryopreserved viable tissue graft, is contained within the continuous interior space of the retainer. Processes for packaging, thawing and rinsing the tissue graft using the tissue graft packaging system and its retainer are also disclosed.

An apparatus to minimize and/or eliminate the effects associated with reperfusion injury consisting of an external pump, heat exchanger and control unit creating a flow loop whereby blood is moved from the body via a pump, cooled by an external heat exchanger and reintroduced into a specific location, thereby locally cooling the surrounding tissue and inducing localized hypothermia to minimize tissue injury resulting from ischemia and the effects associated with reperfusion injury as an obstruction is removed and normal blood flow is restored and including the ability to locally measure pressure and temperature in the body.

Apparatus for treatment of reperfusion injury

Growing community of inventors

Howell, NJ, United States of America

Todd J Nilsen