W. L. Gore & Associates, Inc.

Todd J Johnson

Paul D Drumheller

Robert L Cleek

Robert L Sassa

Theresa A Holland

Karin Leontein

Per Antoni

Richard Winkelmayer

Bruce M Steinhaus

Lars Vincent

Krzysztof R Pietrzak

According to the invention there is provided inter alia a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization.

Drug composition and coating

A filter composite is made of a porous polytetrafluoroethylene (PTFE) and a fabric. The PTFE and fabric are bonded by an adhesive. The adhesive is prevented from penetrating the fabric by employing a coating of an oil and water-repellent material to the surface of the fabric adjacent the adhesive.

Filtration fabric laminates

Growing community of inventors

Flagstaff, AZ, United States of America

Todd J Johnson