Bristol-Myers Squibb Compnay

Celera Corporation

Todd G Kirchgessner

James J Devlin

Olga Iakoubova

Wen-Pin Yang

Yuli Wu

Koustubh Ranade

Peter Shaw

Xin Huang

Zenta Tsuchihashi

Lynn Marie Ploughman

Bonnie Hsiang

Yingjie Zhu

Jean S Lynch

Zhaoqing Wang

Zhaoging Wang

Kim Zerba

Peter Sjaw

The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins ('OATPs'). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Organic anion transport proteins

The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (&ldquo;OATPs&rdquo;). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

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Flemington, NJ, United States of America

Todd G Kirchgessner