Paradigm Genetics, Inc.

Monsanto Technology LLC

Icoria, Inc.

Todd DeZwaan

Matthew M Tanzer

Jeffrey R Shuster

Lisbeth Hamer

Kiichi Adachi

Sanjoy Mahanty

Sheryl Frank

Sze-Chung Lo

Blaise Darveaux

Ryan Heiniger

Amy Skalchunes

Huaqin Pan

Rex Tarpey

Maria Victoria Montenegro-Chamorro

Barry S Goldman

Balasulojini Karunanandaa

Mark Scott Abad

Donald E Nelson

Stephen M Duff

Steven H Schwartz

Erin Bell

Dhanalakshmi Ramachandra

Savitha Madappa

Paul S Chomet

Hongwu Jia

Linda L Lutfiyya

Tyamagondlu V Venkatesh

Huai Wang

Monnanda Somaiah Rajani

Sasha Preuss

Xiaoyun Wu

Zoe P McKiness

Saritha V Kuriakose

Lloyd Jones

Aniruddha Raychaudhuri

Daniel P Schachtman

Char Shobha

Thomas Gene Ruff

Virginia Ursin

Robert J Meister

Deborah J Hawkins

Jeffrey E Ahrens

Paolo Castiglioni

Beth Savidge

Jingrui Wu

Karen Gabbert

Paul J Loida

Wei Zheng

Michael D Edgerton

Richard Eric Cerny

Molian Deng

Jill Deikman

Richard Johnson

Zhidong Xie

Steve Sichuan He

Marie E Petracek

Jaishree M Chittoor-Vijayanath

Jindong Sun

Robert J Bensen

Bradon James Fabbri

Monica P Ravanello

Xianfeng Chen

Obed Patty

Garrett J Lee

Srikanth Babu Venkatachalayya

Maureen Daley

Jason Fenner

Ming Peng

Kammaradi R Vidya

Shobha Char

Anand Pandravada

Rajani Monnanda Somaiah

Rick A Sanders

Padmini Sudarshana

Rebecca L Thompson-Mize

Dale L Vai

Tymagondlu V Venkatesh

K Vijayalakshmi

Todd C Weber

Maria Victoria Montenegro-Chamarro

Matthew M Tänzer

Rex Tarper

Alice Clara Augustine

This invention provides recombinant DNA constructs, transgenic plant nuclei and cells with such recombinant DNA construct for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.

Transgenic plants with enhanced agronomic traits

This disclosure provides recombinant DNA constructs and transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.

Transgenic plants with enhanced traits

The present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Asparagine Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of asparagine synthase as antibiotics

The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of threonine synthase as antibiotics

The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of histidinol-phosphate as antibiotics

The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics

The present inventors have discovered that &agr;-Aminoadipate Reductase is essential for fungal pathogenicity. Specifically, the inhibition of &agr;-Aminoadipate Reductase gene expression in fungi results in no signs of successful infection or lesions. Thus, &agr;-Aminoadipate Reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit &agr;-Aminoadipate Reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of &agr;-aminoadipate reductase as antibiotics

The present inventors have discovered that 5-Aminolevulinate synthase is essential for fungal pathogenicity. Specifically, the inhibition of 5-Aminolevulinate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, 5-Aminolevulinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 5-Aminolevulinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of 5-aminolevulinate synthase as antibiotics

The present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

Methods for the identification of inhibitors of homocitrate synthase as antibiotics

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Apex, NC, United States of America

Todd DeZwaan