Juno Therapeutics Gmbh

Todd Devries

Christopher Glen Ramsborg

Ryan P Larson

Claire L Sutherland

Nathan K Yee

Rachel K Yost

Ronald James Hause, Jr

Kedar Himanshu Dave

Provided are methods, compositions and articles of manufacture for use in cell therapy involving the administration of one or more doses of a therapeutic T cell composition, and methods, compositions and articles of manufacture for use in the same. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the embodiments of the present disclosure, including the dose of cells or units of cells administered and/or the phenotype of administered cells, provide various advantages, such as consistent dosing, lower risk of toxicity and/or increased response in subjects administered the T cell compositions.

Phenotypic markers for cell therapy and related methods

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Seattle, WA, United States of America

Todd Devries