Medtronic Vascular, Inc.

Poly-med, Inc.

Todd Campbell

Shalaby Wahba Shalaby

Kishore Udipi

Peiwen Cheng

Su Ping Lyu

Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.

Biocompatible controlled release coatings for medical devices and related methods

The stent assembly with exterior banding for delivery of therapeutic agents of the present invention comprises a stent and drug coated bands located circumferentially around the stent. The width of the bands allows free flow of blood or other fluids to side branch lumens within the body. Positioning the bands on the abluminal surface prevents the intrusion of the bands into the inner diameter of the stent, thus optimizing patency. The therapeutic agent can vary from band to band, or different therapeutic agents can be included at different radial locations within the band. In an alternate embodiment, the stent assembly can comprise a stent and one or more helical wraps around the stent, the helical wraps including one or more therapeutic agent.

Stent assembly with therapeutic agent exterior banding

One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one conjugated drug. Each conjugated drug includes a control agent and a bioactive agent, where the control agent controls the elution rate of the bioactive agent.

Conjugated drug-polymer coated stent

The present invention provides a system for treating a vascular condition, including a catheter, a stent coupled to the catheter, a polymeric coating on the stent including a segmented homochain copolyester, and a bioactive drug dispersed within the polymeric coating.

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Petaluma, CA, United States of America

Todd Campbell