Hercules Corporation

Astrazeneca Ab

Todd Andrew Brugel

Tuyen T Nguyen

Andrew Griffin

Steven Sigmund Wesolowski

Scott Throner

Denis Labrecque

Phil Edwards

James Arnold

Thierry Groblewski

Osama M Musa

Divya Tewari

Dean Brown

Kelly A Brush

Daiqiang Xu

Sangrama Sahoo

Yuda Zong

The present invention provides novel hybrid polymers having unique physical properties. The hybrid polymers comprise a cellulose ether moiety, a linking group moiety, a spacer group moiety, and a lactam moiety. The present invention also provides compositions comprising the hybrid polymers and methods for preparing and using the hybrid polymers. In a first embodiment, the hybrid polymers have the structure:A-(L-S&#x2014;(B))wherein A is derived from a cellulose ether moiety comprising a &#x2014;OH group; Lis a linking group moiety selected from the group consisting of urethanes, amides, esters, carbonates, and phosphate esters, or is derived from a moiety selected from the group consisting of anhydrides, cyclic ethers, and aziridines; S is a spacer group moiety, selected from the group consisting of straight- or branched-chain functionalized and unfunctionalized alkyl, cycloalkyl, alkenyl, and aryl groups, wherein any of the above groups may be with or without heteroatoms, or is a direct bond; and B is a lactam moiety; wherein k&#x2265;1 and q&#x2265;1. In a second embodiment, the hybrid polymers have the structure:A-(L-S&#x2014;B)wherein A is derived from a cellulose ether moiety comprising a &#x2014;OH group; Lis an ether linking group moiety; S is a spacer group moiety, selected from the group consisting of straight- or branched-chain functionalized and unfunctionalized alkyl, cycloalkyl, alkenyl, and aryl groups, wherein any of the above groups may be with or without heteroatoms, or is a direct bond; and B is a lactam moiety; wherein y&#x2265;1; with the proviso that when the cellulose ether moiety is hydroxyethyl cellulose, -(L-S&#x2014;B)is not derived from 1-(hydroxymethyl)-2-pyrrolidinone.

Cellulose ether-lactam hybrid polymers, compositions, and methods for preparing and using the hybrid polymers

A lactam-functionalized polymer is disclosed. The lactam-functionalized polymer includes lactam-functionalized polyacetal polyether, polyhemiaminal polyether or polyaminal polyether. The applications of the lactam-functionalized polymer are also disclosed.

Lactam-functionalized polymer, compositions and applications thereof

The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position.

Pharmaceutical compositions with enhanced performance and improved processability

Disclosed herein is at least one cyclopropyl amide derivative, at least one pharmaceutical composition comprising at least one cyclopropyl amide derivative disclosed herein, and at least one method of using at least one cyclopropyl amide derivative disclosed herein for treating at least one histamine H3 receptor associated condition therewith.

Cyclopropyl amide derivatives

Growing community of inventors

Wilmington, DE, United States of America

Todd Andrew Brugel