University of Michigan

Harrier Inc.

Todd A Houston

Masato Koreeda

Brian Keith Shull

Roeland J Tuinman

R -Erich Klemke

R Erich Klemke

Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.

Glycoside compounds and methods of synthesis

Glycoside derivatives of acetaminophen

The invention concerns C-glycosylated derivatives of soft carbon nucleophile compounds, particularly compounds which contain acid-labile structural units. The invention further concerns a mild, cost-effective, non-hazardous and stereoselective method of general application employing a glycal as a glycosyulating agent and iodine as a catalyst for the preparation of C-glycosylated soft carbon nucleophile compounds.

Synthesis of C-glycosylated compounds with the use of a mild,

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Glen Allen, VA, United States of America

Todd A Houston