Biocircuits Corporation

Todd A Guion

Hans Oliver Ribi

John Campbell Scott

Paul T Shafer

Glenda L Choate

Joseph R Murdoch

Victor Pan

Tom Saul

Henry L Schwartz

An electro-optical instrument for measuring a quantitative physical parameter of a sample in a diagnostic cartridge is provided.

Apparatus for automatic electro-optical chemical assay determination

Bioelectronic sensors are provided employing a thin surfactant polymeric electrically conducting layer to which may be bound members of specific binding pairs. Binding of an analyte or a reagent to the specific binding pair member layer may change the electrical, optical, or structural properties of the layer for measurement of analyte. The change in the polymeric layer provides for a sensitive measurement.

Multilayered bioelectronic sensors

Methods are provided for the detection of an analyte in a sample using a bioelectronic sensor comprising a thin surfactant polymeric electrically conducting layer to which members of specific binding pairs are bound. Specific binding of analyte or analyte competitor to the bound specific binding pair member results in a change in the conductivity of the polymer. The resultant change in conductivity is related to the presence of analyte in the sample.

Analyte detection with multilayered bioelectronic conductivity sensors

Apparatus and methods are provided for the detection of analytes. A polyunsaturated polymerized lipid layer is employed, which is anisotropic, has a member of a specific binding pair bound to an end of the lipids, and whose optical characteristics are modified upon complex formation between the specific binding pair member and its complementary member. By providing for polarized light, linear and/or circular, one can detect the presence of complex formation by the change in the optical characteristics of the film. Polarizers, analyzers, and wave plates are employed for providing for a light signal which can be analyzed and related to the presence of an analyte in a sample.

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Burlingame, CA, United States of America

Todd A Guion