Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Todao Tanimoto

Masashi Kurimoto

Shigeharu Fukuda

Haruki Okamura

Kakuji Torigoe

Keizo Kohno

Mutsuko Taniguchi

Toshio Kunikata

Shimpei Ushio

A human IFN-&#x3b3; inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel INF-&#x3b3; inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with INF-&#x3b3;, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.

Interferon-&#x3b3; inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use

A human IFN-&#x3b3; inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel IFN-&#x3b3; inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with IFN-&#x3b3;, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.

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Okayama, Japan

Todao Tanimoto