Sterix Limited

Other

Toby Jackson

Michael John Reed

Atul Purohit

Lok Wai Lawrence Woo

Barry Victor Lloyd Potter

Christian Bubert

Gillian Reed, Legal Representative

Barry Victory Lloyd Potter

There is provided a compound of Formula I wherein X, Y and Z are each independently of each other an optional linker group; Ris a ring system; Ris selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (&#x2014;CN), nitro (&#x2014;NO) and halogens; Rand Rare independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.

Phenyl-sulfamates as aromatase inhibitors

There is provided a compound of Formula I wherein R, R, R, Rand Rare independently selected from H and &#x2014;Y&#x2014;R; wherein each Ris independently selected from &#x2014;OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (&#x2014;CN), nitro (&#x2014;NO), H-bond acceptors, and halogens; wherein at least one of R, R, R, Rand Ris &#x2014;Y&#x2014;Rwherein Ris selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein Ris selected from H, &#x2014;OH and &#x2014;OSONRR; wherein Rand Rare independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R, R, R, Rand Ris &#x2014;Y&#x2014;R; OR (b) Ris &#x2014;OSONRRor &#x2014;OH and four of R, R, R, Rand Rare H and one of R, R, R, Rand Ris &#x2014;Y&#x2014;R.

Compound

There is provided a compound of Formula I wherein R, R, R, Rand Rare independently selected from H and &#x2014;Y&#x2014;R; wherein each Ris independently selected from &#x2014;OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (&#x2014;CN), nitro (&#x2014;NO), H-bond acceptors, and halogens; wherein at least one of R, R, R, Rand Ris &#x2014;Y&#x2014;Rwherein Ris selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein Ris selected from H, &#x2014;OH and &#x2014;OSONRR; wherein Rand Rare independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R, R, R, Rand Ris &#x2014;Y&#x2014;R; OR (b) Ris &#x2014;OSONRRor &#x2014;OH and four of R, R, R, Rand Rare H and one of R, R, R, Rand Ris &#x2014;Y&#x2014;R. These compounds inhibit steroid sulphatase and aromatase activity and are useful in the treatment of endocrine-dependent tumors.

1,2,4-triazol-1-yl bisphenyl derivatives for use in the treatment of endocrine-dependent tumors

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Slough, United Kingdom

Toby Jackson