The Governors of the University of Alberta

Medizinische Hochschule Hannover

Tobias Weismueller

Michael Houghton

D Lorne Tyrrell

Abdolamir Landi

Michael Manns

Tim Lankisch

Lorne D Tyrrell

The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.

Methods and compositions for treatment of autoimmune hepatitis

Methods of treatment of primary sclerosing cholangitis

Methods and compositions for diagnosis of inflammatory liver disease

Growing community of inventors

Hannover, Germany

Tobias Weismueller