Harvard College

Studiengesellschaft Kohle Mbh

Tobias Ritter

Takeru Furuya

Constanze Neumann

Pingping Tang

Debashis Mandal

Eunsung Lee

Martin Georg Strebl-Bantillo

Kumiko Yamamoto

Florian Berger

Jean B Raynaud

Jessica Yung Wu

Mohammad Hassan Beyzavi

David Powers

Jeffrey Garber

Fei Ye

The present invention refers to a process for direct C&#x2014;H functionalization, the reagents used in the process and the use thereof for the direct C&#x2014;H functionalization as well as the so-obtained products.

Reagents and process for direct C&#x2014;H functionalization

Provided herein are palladium complexes comprising a ligand of Formula (A') and a ligand of Formula (B), wherein R-Rare as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes. 

Direct palladium-catalyzed aromatic fluorination

The present invention refers to a process for transition-metal-assistedF-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.

Process for deoxyfluorination of phenols

The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.

Process for hydrocyanation of terminal alkynes

Methods for fluorinating organic compounds utilizing a novel organic reagent are described herein. The invention further discloses the utility of this reagent for incorporation of the 18 F isotope into hydroxyl group-containing organic molecules for PET imaging studies. Preparation of the reagents is described along with isolable intermediate structures from reaction of the reagent with a hydroxyl group-containing organic molecule.

Fluorination of organic compounds

Provided are methods of preparing polymers, such as polyisoprene, polybutadiene, polypiperylene, polycyclohexadiene, poly-&#x3b2;-farnesene, or poly-&#x3b2;-myrcene, using iron complexes. Also provided are novel iron complexes, pre-catalysts, intermediates, and ligands useful in the inventive polymerization system.

Iron complexes and methods for polymerization

The present invention provides novel nickel complexes. These complexes are in providing fluorinating organic compounds. The invention is particularly useful for fluorinating compounds withF for PET imaging.

Nickel fluorinating complexes and uses thereof

Methods for fluorinating organic compounds are described herein.

The present invention provides novel high-valent palladium fluoride complexes. The complexes typically include multi-dentate ligands that stabilize the octahedral coordination sphere of the palladium(IV) atom. These complexes are useful in fluorinating organic compounds, in particular aryl-containing compounds. The invention is particularly useful for fluorinating compounds withF for PET imaging.

Growing community of inventors

Cambridge, MA, United States of America

Tobias Ritter