Sanofi-a Ventis Deutschland Gmbh

Sanofi

Tobias Metzenthin

Joachim Graeser

Javier Manero

Adolf Heinz Linkies

Guenter Billen

Bernd Henkel

Richard Bicker

Wolfgang Fiedler

Manfred Gerken

Rainer Gauler

Claus-Jürgen Maier

The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).

Capping of unprotected amino groups during peptide synthesis

This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.

Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives

This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.

The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.

Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use

A process is described for preparing compounds of formula (I)where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CHgroups may be replaced by &#x2014;O&#x2014;. The compounds of the formula (I) are valuable intermediates in the synthesis of PPAR agonists.

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Hofheim, Germany

Tobias Metzenthin