Merck & Cie

Merck Eprova Ag

Tobias Ludwig Ross

Rudolf Moser

Viola Groehn

Simon Mensah Ametamey

Roger Schibli

Cristina Magdalena Muller

Thomas Leighton Mindt

Cristina Magdalena Mueller

Phoebe Lam

Cristina Magdalena MÜLLER

The present invention is directed towards newF-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.

F-labelled folates as PET radiotracers

The present invention is directed towards a new method of synthesis ofF-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with[F]fluoride, as well asF-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.

F-labelled folates

The present invention is directed towards newF-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

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18F-labelled folates

The present invention is directed towards newF-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.

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Zurich, Switzerland

Tobias Ludwig Ross