Roche Molecular Systems, Inc.

Roche Diagnostics Operations, Inc.

Tobias Holenstein

Carsten Haack

Thomas Engel

Renato Belz

Rolf Schneebeli

Alessandro D'Amore

Adelrich Zuppiger

Roland Stoeckli

Thomas Sidler

Michael Meyberg

Tobias Greuter

An apparatus for separating magnetic particles from a liquid which contains said particles, said liquid being contained in an elongated vessel () having a length axis (), said vessel being arranged in a vessel holder () with its length axis () in a substantially vertical position, said vessel () having a bottom and a tapered cross-section that diminishes towards the bottom of the vessel and a side wall () which has an outer surface which forms an angle with the length axis () of said vessel (). This apparatus comprises a magnet () having a plane outer surface () and being adapted for being moved by transport means () along a motion path (), said magnet () and said transport means () being so arranged with respect to said vessel () that over a portion of said motion path () said plane outer surface () of said magnet is in contact with a portion of said outer surface of said side wall () of said vessel (), and transport means () for moving said magnet () between a first predetermined position and a second predetermined position along said motion path ().

Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus

A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.

Pipetting device, modular pipetting unit, pipetting system and method for pipetting of fluid samples

A sample preparation dosing unit for liquid dosing is provided comprising an inlet port and an outlet port fluidically coupling the sample preparation dosing unit to a supply and target, respectively; a pump, fluidically arranged between the inlet port and the outlet port; an outlet flow restrictor with an outlet flow resistance, fluidically arranged between a pump outlet and outlet port; and a control arrangement with a branch, a control valve, and a control flow restrictor with a control flow resistance. The branch divides the flow at the pump outlet into an outlet flow through the outlet flow restrictor and into a control flow through the control flow restrictor. The control flow downstream of the control flow restrictor is fed, depending on the state of the control valve, either into the outlet port thereby merging with the outlet flow downstream of the outlet flow restrictor, or into a bypass conduit.

Sample preparation dosing unit

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Kuessnacht am Rigi, Switzerland

Tobias Holenstein