Italfarmaco Sud S.p.a.

Chemi S.p.a.

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Tiziana Benincori

Patrizia Antognazza

Elisabetta Brenna

Edoardo Cesarotti

Licia Trimarco

Francesco Sannicolo'

Francesco Sannicolo

Francesco Sannicolo&prime;

Piero Del Soldato

Lorenzo De Ferra

Oreste Piccolo

Mara Sada

Elio Ullucci

Alessandra Verrazzani

Serafino Gladiali

Simona Tollis

Simona Rizzo

Francesco Sannicolo′

Metallic catalysts of the general formula (I) and their precursors, suitable for chemo- regio- and stereoselective reactions, derived from ortho-bis-(1-phospholanyl)-heteroarenes. The new catalysts are characterized by the presence of two homo-morphic phospholanic rings set in adjacent positions of an aromatic pentatomic heterocycle 

Metallic catalysts for chemo-, regio- and stereoselective reactions, and corresponding precursors

Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in sterocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process for the preparation of said chiral diphosophines and process for the preparation of said complexes and for their utilization as chiral catalysts in sterocontrolled reactions.

Heteroaromatic diphosphines as chiral ligands

Process for the preparation of a pharmacologically active chemical combination constituted by the association, through chemical bonds, of units equal to one another, having each an own pharmacological activity, and with the general formula (I): M&mdash;A&mdash;X&mdash;B&mdash;M, where M indicates said unit having an own pharmacological activity, X indicates a &ldquo;bidentate&rdquo; structure suitable to interconnect the M units, A and B indicate functional groups either equal to or different from one another which allow the interconnection between M and X.

Process for the preparation of a pharmacologically active chemical combination

Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in stereocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process for the preparation of said chiral diphosophines and process for the preparation of said complexes and for their utilization as chiral catalysts in stereocontrolled reaction.

Heteroarylic-arylic diphosphines as chiral ligands

Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in stereocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process for the preparation of said chiral diphosophines and process for the preparation of said complexes and for their utilization as chiral catalysts in stereocontrolled reactions.

Chiral diphosphines are constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands and complexes between the diphosphines and transition metals. They may be utilized as chiral catalysts in stereocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process is for the preparation of these chiral diphosphines; and process is for the preparation of these complexes and for their utilization as chiral catalysts in stereocontrolled reactions.

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Milan, Italy

Tiziana Benincori