Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

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Teva Gyógyszergyár Zárkörüen Müködö Részvénytársaság

Tivadar Tamas

Csaba Szabo

Sandor Janos Molnar

Janos Hajko

Adrienne Kovacsne-Mezei

Judith Aronhime

Irun R Cohen

Jeffrey Sterling

Meir Shinitzky

Yaacov Herzig

Raanan Margalit

Istvan Miskolczi

Szabolcs Salyi

Amihai Eisenstadt

Gyorgy Toth

Ferenc Rantal

Erzsebet Meszaros Sos

Erika Magyar Molnarne

Csaba Peto

Beáta Kosztya

Kovacsne-Mezei; Adrienne

Basic esters of fatty alcohols of the general formula: R1-O&#x2014;CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C-Calkyl or C-Calkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.

Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents

The present invention provides an improved process for the preparation of Dolasetron salts, in particularly Dolasetron mesylate. Also provided are intermediates for the process and methods of preparing the intermediates.

Production of dolasetron

Provided are crystalline mycophenolate sodium forms and processes for their preparation.

Crystalline mycophenolate sodium

Provided is an impurity of mycophenolate mofetil, processes for its preparation and its use as a reference.

Mycophenolate mofetil impurity

A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.

Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one

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Debrecen, Hungary

Tivadar Tamas