Tae Life Sciences, LLC

Tioga J Martin

Michael Torgov

Arthur B Raitano

Borylated Amino Acid compositions comprising tyrosine derivatives BTS and BTS(OMe) and novel methods of making BTS and BTS(OMe) are disclosed herein. Consequently, the BTS and/or BTS(OMe) can be scaled up to commercial scale and administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders, and other disease by utilizing a Neutron Capture Therapy modality.

Dosage unit form(s) comprising BTS and BTS(OMe) for use in boron neutron capture therapy and methods thereof

Borylated Amino Acid ('BAA') compositions and methods of making BAAs are disclosed herein. Consequently, the BAAs can be administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders and other disease by utilizing a Neutron Capture Therapy modality.

Borylated amino acid compositions for use in boron neutron capture therapy and methods thereof

Borylated amino acid compositions comprising BTS and BTS(OMe) for use in boron neutron capture therapy and methods thereof

Boron Enriched Linker ('BEL') compositions and methods of making BELs are disclosed herein. Consequently, the BELs can be conjugated to antibodies or antibody fragments to create Antibody Boron Conjugates ('ABCs') to provide a method of treating cancer, immunological disorders and other disease by utilizing a Neutron Capture Therapy modality.

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Los Angeles, CA, United States of America

Tioga J Martin