National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Pittsburgh

University of Louisville Research Foundation, Inc.

Other

Tinoush Moulaei

Barry R O'Keefe

Lisa C Rohan

Kenneth E Palmer

Joshua L Fuqua

Lindsay F Kramzer

Alexander Wlodawer

Barry R O'keefe

The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.

Griffithsin mutants

The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the construct, a nucleic acid encoding the construct or conjugate, vectors, and cells. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.

Monomeric griffithsin tandemers

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College Park, MD, United States of America

Tinoush Moulaei