Glaxo Inc.

Glaxo Wellcome Spa

Glaxosmithkline LLC

Tino Rossi

Giovanni Gaviraghi

Alcide Perboni

Daniele Andreotti

Stefano Biondi

Daniele Donati

Claudio Bismara

Roberto Carlesso

Bruno Tamburini

Luca Tarsi

Antonella Ursini

Giovanna Tedesco

Giorgio Tarzia

Aldo Feriani

Domenica Antonia Pizzi

Emiliangelo Ratti

Gabriella Finizia

Stuart Holman

John Russel Thomas

Paola Zarantonello

Russell John Thomas

Stefania Anna Contini

A compound of formula (I), salts and metabolically labile esters thereof, wherein R represents optionally substituted aryl or heteroaryl group; A represents a propylene chain or A is a chain of members one of which is selected from an oxygen or sulphur atom or the group NH or a substituted derivative thereof and the other two members are methylene groups, having antibacterial activity, processes for their preparation and to their use in medicine.

Tricyclic carbapenem compounds

Process for the preparation of cyclohexyl-azetidinones

Compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen or a nitrogen protecting group, useful as intermediates in the preparation of compounds having antibacterial activity.

Cyclohexene derivatives

A compound of the formula 1-cyclohexyloxycarbonyloxethyl (4S, 8S, 9R 10S, 12R)-4-methoxy-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0..sup.3,8 ]undec-2-ene-2-carboxylate which is useful as a pharmaceutical composition to treat bacterial infection.

10(1-hydroxyethyl)-11-oxo-1-azatricyclo/7.2.0.0..sup.3.8/

1-azatricyclo[7.2.0.0.sup.3,8 ]undec-2-ene-2-carboxylates as

The invention relates to heterocyclic derivatives having antibacterial activity, to processes for their preparation, to compositions containing them, and to their medicinal uses. The derivatives according to the invention have the following general formula: ##STR1##

Derivatives of 1-azatricyclo[7.2.03,8]undec-2-ene-2-carboxyclic acid

Compounds of the general formula (I) ##STR1## in which: R.sub.1 represents a hydroxyl protecting group; and

4-(2-Oxo-cyclohexyl) azetidinones

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Verona, Italy

Tino Rossi