Robert Boschgmbh

Tino Frank

Jochen Rupp

Karsten Seidl

Jochen Hoffmann

Robert Schreiner

Genrich Siris

A method for detecting characteristic cells in a sample includes performing a first lysis of a sample to yield a first lysate wherein nuclei of the cells of the sample remain intact. Freely available RNA in the first lysate is extracted and classified to ascertain the amounts of various types of RNA in the first lysate. A second lysis operation on the previously lysed sample is performed to yield a second lysate wherein the cell nuclei of the cells in the sample are destroyed. DNA freely available in the second lysate is extracted and a total cell count of cells in the provided sample is calculated on the basis of the amount of extracted DNA. The number of cells having individual cell markers in the provided sample is calculated using the ascertained amounts of various types of RNA and the calculated total cell count.

Method for counting cell types or cell markers in a sample, in particular in a blood sample

A filter device for an optical module for a lab-on-a-chip analysis device, in which the optical module has a light path, includes a support element, a filter support, and a drive device. The support element can be mounted in the optical module. The filter support is arranged so that it can move on the support element. The filter support also has a first filter region and a second filter region. The drive device is configured such that the filter support can move between a first position in which the first filter region is arranged in the light path, and a second position in which the second filter region is arranged in the light path.

Filter device for an optical module for a lab-on-a-chip analysis device, optical module for a lab-on-a-chip analysis device and method for operating an optical module for a lab-on-a-chip analysis device

A method for providing a solution of a substance in a microfluidic device includes providing a dispersion of a first medium and of a lyophilizate of the substance, the lyophilizate being insoluble in the first medium, and adding a second medium to the dispersion, the lyophilizate being soluble in the second medium. The method further includes dissolving the lyophilizate in the second medium such that the solution of the substance in the second medium is obtained, and separating the solution obtained by the dissolving of the lyophilizate from the first medium.

Method for providing a solution of the substance in a microfluidic device

A method for measuring a temperature of a fluid for use with a microfluidic analysis apparatus includes a reading step and a determination step. During the reading step, at least one diffusion signal is read, the latter representing a diffusion characteristic of the diffusion of the fluid. During the determination step, the temperature is determined using the at least one diffusion signal.

Method and apparatus for measuring a temperature of a fluid for use with a microfluidic analysis apparatus, and microfluidic analysis apparatus comprising an apparatus

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Lucerne, Switzerland

Tino Frank