Tencent Technology (Shenzhen) Company Limited

Lanzhou University

Tingyang Xu

Shuo Liu

Junzhou Huang

Yu Rong

Wenbing Huang

Xiaojun Yao

Qifeng Bai

Liya Feng

Huanxiang Liu

The present disclosure provides a compound and use thereof as a glucagon receptor antagonist. The compound includes a compound A, or an isomer, metabolite, prodrug, pharmaceutically acceptable ester, or pharmaceutically acceptable salt of the compound A. The glucagon receptor antagonist in the present disclosure has a novel skeleton structure and a low half maximal inhibitory concentration on the glucagon receptor.

Glucagon receptor antagonist and use thereof

A compound property prediction method is provided for an electronic device. The method includes obtaining chemical structure information of a target compound, the chemical structure information including an atom and a chemical bond, modeling a chemical structure graph according to the chemical structure information, the chemical structure graph including a first node corresponding to the atom and a first edge corresponding to the chemical bond, constructing an original node feature of the first node and an original edge feature of the first edge, performing a message propagation on the first edge according to the original node feature of the first node and the original edge feature of the first edge to obtain propagation state information of the first edge, and predicting properties of the target compound according to the propagation state information of the first edge.

Compound property prediction method and apparatus, computer device, and readable storage medium

Growing community of inventors

Shenzhen, China

Tingyang Xu