Merck Sharp + Dohme Corp.

Enraytek Optoelectronics Co., Ltd.

Verisilicon Microelectronics (shanghai) Co., Ltd.

Shanghai Biren Technology Co., Ltd

Verisilicon Microelectronics (nanjing) Co., Ltd.

Shanghai Shangwang Network Technology Co., Ltd.

Verisilicon Microelectronics (chengdu) Co., Ltd.

Tingting Yu

Yunfu Luo

Scott D Kuduk

Nigel J Liverton

Na Meng

Craig Alan Coburn

Douglas C Beshore

Milana M Maletic

Zhiqi Qi

Qiming Li

Richard Soll

Shuai Zhang

Huiwen Xu

Chunsing Li

Amjad Ali

Sung-Sau So

Scott D Edmondson

Chun Sing Li

Zhuyan Guo

Ying-Duo Gao

Rongze Kuang

Anthony K Ogawa

Ke Zhang

Yu Jiang

Weiguo Liu

Heping Wu

WenQi Li

Linglan Zhang

YiKai Liang

Zheng Tian

Jon Christian Baber

DongCai Li

Jing Zhang

Shuxi Lin

Bhuamik Pandya

Xin Zhang

Jan Antoinette C Romero

Milania M Maletic

Yunfun Luo

Provided are cross-linking method and apparatus, electronic device and storage medium. The method includes: modifying a register address in a first operation instruction of a library function after the register address in the first operation instruction hits a preset mapping table, wherein the mapping table includes a mapping relationship between a target register address of a main program and the register address of the library function, the target register address of the main program is increased to a first address bit number, the register address in the operation instruction of the library function has a second address bit number, the first address bit number is greater than the second address bit number, and the modified register address in the first operation instruction is the target register address of the corresponding main program in the mapping table; and migrating the modified first operation instruction into the main program.

Cross-linking method and apparatus, electronic device and storage medium

A method and a device for hotspot leasing are provided. The method comprises: acquiring a data request packet transmitted by a requesting user (S); based on a target data request packet acquired by a supplying user from the data request packet, transmitting hotspot information provided by the supplying user to the requesting user corresponding to the target data request packet, and establishing a hotspot leasing contract between the requesting user and the supplying user (S). Therefore, demand docking is provided for both parties of leasing and selling by means of the data request packet, so that users with excess data provide data to users with data gaps. Urgent needs of one or more surrounding users are solved, near-field social contact for mutual assistance is established, and data utilization is improved.

Method and a device for hotspot leasing

The disclosure provides a clock step control circuit and a method thereof. The clock step control circuit includes a clock divider, a multiplexer, and a controller. The clock divider receives a first clock signal and outputs multiple second clock signals. The multiplexer receives the second clock signals and outputs one of the second clock signals. The controller is coupled to the clock divider and the multiplexer. When the controller receives an interrupt signal, the controller outputs a selection signal to the multiplexer according to the interrupt signal. The multiplexer outputs another one of the second clock signals according to the selection signal. The clock step control circuit and the method thereof in the disclosure can appropriately switch the clock signal to output a clock signal with an appropriate clock frequency.

Clock step control circuit and method thereof

The present invention relates to piperidine or piperazine linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.

Piperidine or piperazine linked imidazole and triazole derivatives and methods of use

The present invention is directed to piperidine oxadiazole and thiadiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

Piperidine oxadiazole and thiadiazole orexin receptor antagonists

The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. Such compounds are of the general structural formula I: wherein the variables are defined herein. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

Piperidine isoxazole and isothiazole orexin receptor antagonists

The present invention relates to Imidazole Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, B, Y, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Imidazole Derivative, and methods of using the Imidazole Derivatives for inhibiting CYP450 3A. Inhibition of CYP450 3A can be used to improve the pharmacokinetics of a drug that is metabolized by CYP450 3A4. 

Imidazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug

The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.

Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein. 

Factor XIa inhibitors

The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

Oxazole orexin receptor antagonists

LED chip

The present invention is directed to thiazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thiazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

Thiazole orexin receptor antagonists

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Shanghai, China

Tingting Yu