Sunshine Lake Pharma Co., Ltd.

Calitor Sciences, LLC

North & South Brother Pharmacy Investment Company Limited

Tingjin Wang

Ning Xi

Liang Wang

Qian Wang

Minxiong Li

Xiaobo Li

Weilong Dai

Mingming Sun

Yin Tang

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

Substituted aminopyrimidine compounds and methods of use

The present invention provides substituted azaindole prodrugs, methods of making said prodrugs, pharmaceutical compositions of said prodrugs and methods of using said prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer.

Substituted azaindole compounds, salts, pharmaceutical compositions thereof and methods of use

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

Substituted heteroaryl compounds and methods of use

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Guangdong, China

Tingjin Wang