Aecc Commercial Aircraft Engine Co., Ltd.

Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

Shanghai Hansoh Biomedical Co., Ltd.

Changzhou Hansoh Pharmaceutical Co., Ltd.

Water Bear Health Technology (nantong) Co., Ltd.

Ykk Corporation

Ting Zhang

Lei Zhang

Weikang Tao

Hua Ying

Ling Zhang

Jianyan Xu

Xudong Wan

Xianting Ding

Aihua Huang

Li Luo

Haiyang Xie

Naixian Hou

Ainur Abula

Xiangqian Li

Hong Wan

Disclosed by the present invention are an anti-B7H3 antibody-exatecan analog conjugate, a preparation method therefor and an anti-tumor medicinal use thereof.

Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof

A microfluidic chip comprises: a first unit which has a channel for a cell sample to pass through and is configured to separate circulating tumor cells in the cell sample; a second unit, a front end of which communicates with a tail end of the first unit, and the second unit is configured to capture single cells from the separated circulating tumor cells and subject the captured single cells to closed lysis; and a gel layer which is provided at the second unit. The microfluidic chip is configured to implement the binding of a protein molecule of the single cell with an antibody in the gel layer after the single cell is lysed. A cell separation and western blotting method using the microfluidic chip comprises: lysing circulating tumor cells, capturing, and implementing the binding of a lysate with an antibody. A manufacture method of the microfluidic chip, comprises: manufacturing a first interlayer and a separation unit; manufacturing a second interlayer and pasting the second interlayer on a basal layer, and manufacturing a single-cell capture unit; and bonding the first interlayer with the separation unit and the second interlayer with the single-cell capture unit.

Microfluidic chip and manufacture method thereof, and cell separation and single-cell western blotting method

The present disclosure provides a vibration exciting system and an apparatus for testing an aero-engine rotor, relating to the field of aero-engines, to improve the universality of the vibration exciting system. The vibration exciting system comprises a mounting ring, fixing parts, holders, guide rails, and nozzle assemblies. The mounting ring is configured to be annular; one ends of the fixing parts are fixedly connected to the mounting ring; the holders are slidably mounted at the other ends of the fixing parts, the plurality of holders being arranged circumferentially of the mounting ring; each guide rail connects two adjacent holders, connection positions of the guide rail and the holders being adjustable; and the nozzle assemblies are mounted on the holders. The radius size of a spraying area enclosed by the nozzle assemblies is adjusted by adjusting the positions of the holders on the fixing parts.

Vibration exciting system and apparatus for testing aero-engine rotor

The present disclosure provides a method of manufacturing a bonding structural test block with defects. The method of manufacturing the bonding structural test block with defects includes: providing a first plate and a second plate; applying an adhesive on an upper surface of the first plate to form an adhesive layer; heating and curing at least partial region of the adhesive layer for the first time; placing the second plate on the adhesive layer; and heating and curing the adhesive layer for the second time to form a boding structural test block. According to the present disclosure, the at least partial region of the adhesive layer is heated and cured for the first time and chemical reaction occurs, so that the at least partial region forms a defect, and controllable manufacturing of the defect is realized. The test block with the defect is subjected to mechanical detection to simulate the actual defective product. Furthermore, according to the method provided by the present disclosure, weak bond defect and kiss-bonds defect with different bonding strength are simulated by controlling the percentage of the at least partial region in the entire region of the adhesive layer.

Method of manufacturing bonding structural test block with defects

Growing community of inventors

Shanghai, China

Ting Zhang