Xiamen University

Boston University

Ting Zhang

Xianming Deng

Zhiyu Hu

Qingyan Xu

Wei Peng Huang

Zhou Deng

Li Li

Xihuan Sun

Jingfang Zhang

Yan Liu

Xiaoyang Li

Shuang Liu

Chao Dong

Xiaoxing Huang

Baoding Zhang

Zhixiang He

Zaiyou Yang

Jiaji Zhong

Yun Chen

Hongrui Wang

Taoling Zeng

Xinrui Wu

Tingting Jiang

Zhongji Zhuang

Rutao Cui

Chengqian Yin

Qiaofeng Kang

Wei Huang

Yanru Yang

Provided herein are compositions and methods for the treatment and prevention of cancer, including melanoma.

STK19 inhibitors for treatment of cancer

A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof

The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification. 

Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof

The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis. 

Five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof

The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification. 

Pyrimidopyrrole compounds, method for preparing the same, pharmaceutical compositions comprising the same and uses thereof

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Xiamen, China

Ting Zhang